4-tert-butyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine
4-tert-butyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine
CAS: 213383-02-9
Molecular Formula: C28H29NO4
4-tert-butyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine - Names and Identifiers
| Name | 4-tert-butyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine |
| Synonyms | FMOC-PHE(4-TBU)-OH FMOC-PHE(P-TBU)-OH RARECHEM BK PT 0189 FMOC-P-TBU-L-PHE-OH FMOC-L-4-TERT-BUTYL-PHE Fmoc-L-4-Tert-Butyl-Phe FMOC-P-TBU-PHENYLALANINE FMOC-4-T-BUTYL-L-PHENYLALANINE Fmoc-L-4-tetr-Butylphenylalanine Fmoc-4-tert-butyl-L-phenylalanine N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-(4-T-BUTYL)-L-PHENYLALANINE 4-tert-butyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine (S)-3-(4-TERT-BUTYL-PHENYL)-2-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-PROPIONIC ACID |
| CAS | 213383-02-9 |
| InChI | InChI=1/C28H29NO4/c1-28(2,3)19-14-12-18(13-15-19)16-25(26(30)31)29-27(32)33-17-24-22-10-6-4-8-20(22)21-9-5-7-11-23(21)24/h4-15,24-25H,16-17H2,1-3H3,(H,29,32)(H,30,31)/t25-/m0/s1 |
4-tert-butyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine - Physico-chemical Properties
| Molecular Formula | C28H29NO4 |
| Molar Mass | 443.53 |
| Density | 1.198±0.06 g/cm3(Predicted) |
| Boling Point | 637.9±55.0 °C(Predicted) |
| Flash Point | 339.6°C |
| Vapor Presure | 3.82E-17mmHg at 25°C |
| pKa | 3.81±0.10(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Refractive Index | 1.6 |
4-tert-butyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine - Risk and Safety
| Hazard Symbols | Xi - Irritant |
4-tert-butyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine - Introduction
4-tert-butyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine is an amino acid derivative that contains an L-phenylalanine group and a protecting group, the Fmoc group, in its chemical structure. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: White or off-white crystalline powder
-molecular formula: C24H27NO4
-Molecular Weight: 393.48
-Melting Point: about 166-169 ℃
-Solubility: Soluble in N,N-dimethylformamide (DMF) and dichloromethane (DCM)
Use:
4-tert-butyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine is an important amino acid derivative, which is widely used in organic synthesis and solid phase synthesis. Its Main uses include:
-Solid phase peptide synthesis: As a protecting group and amino acid monomer in peptide synthesis, it is used for peptide chain extension and modification.
-Drug research: For Drug Synthesis, modification and drug molecular exploration.
-Biological activity Research: used to study the biological activity and mechanism of action of peptide molecules.
Method:
The preparation of 4-tert-butyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine is generally carried out by organic synthesis methods. A common synthetic route is to react Fmoc-L-phenylalanine with Fmoc-OSu(Fmoc-N-hydroxysuccinimide) under basic conditions to give 4-tert-butyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine.
Safety Information:
4-tert-butyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine is generally relatively safe under normal conditions of use, the following matters still need to be noted:
-Avoid contact with skin and eyes. If there is contact, rinse immediately with sufficient water.
-During use, appropriate protective measures should be taken, such as wearing gloves and protective glasses.
-Follow laboratory safety procedures and ensure good ventilation in the operating area.
-Avoid contact with oxidizing agents and violent reactants during storage, and store in a dry and cool place.
Nature:
-Appearance: White or off-white crystalline powder
-molecular formula: C24H27NO4
-Molecular Weight: 393.48
-Melting Point: about 166-169 ℃
-Solubility: Soluble in N,N-dimethylformamide (DMF) and dichloromethane (DCM)
Use:
4-tert-butyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine is an important amino acid derivative, which is widely used in organic synthesis and solid phase synthesis. Its Main uses include:
-Solid phase peptide synthesis: As a protecting group and amino acid monomer in peptide synthesis, it is used for peptide chain extension and modification.
-Drug research: For Drug Synthesis, modification and drug molecular exploration.
-Biological activity Research: used to study the biological activity and mechanism of action of peptide molecules.
Method:
The preparation of 4-tert-butyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine is generally carried out by organic synthesis methods. A common synthetic route is to react Fmoc-L-phenylalanine with Fmoc-OSu(Fmoc-N-hydroxysuccinimide) under basic conditions to give 4-tert-butyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine.
Safety Information:
4-tert-butyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine is generally relatively safe under normal conditions of use, the following matters still need to be noted:
-Avoid contact with skin and eyes. If there is contact, rinse immediately with sufficient water.
-During use, appropriate protective measures should be taken, such as wearing gloves and protective glasses.
-Follow laboratory safety procedures and ensure good ventilation in the operating area.
-Avoid contact with oxidizing agents and violent reactants during storage, and store in a dry and cool place.
Last Update：2024-04-09 02:00:44
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View History
4-tert-butyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine
2-Fluoro-5-(trifluoromethyl)aniline
124932-43-0
Pentoxifylline
138775-48-1
41964-07-2
2-Amino-3-nitro-6-phenylpyridine
131020-57-0
143426-50-0
81131-40-0
2-Fluoro-5-(trifluoromethyl)aniline
124932-43-0
Pentoxifylline
138775-48-1
41964-07-2
2-Amino-3-nitro-6-phenylpyridine
131020-57-0
143426-50-0
81131-40-0